Dupont research demonstrates impact of strain specificity on human milk oligosaccharide utilization

Date: 15.10.2020Source: DuPont Nutrition & Biosciences

Continuing its research on human milk oligosaccharides (HMOs), DuPont Nutrition & Biosciences released the findings of a new study demonstrating the importance of probiotic strain specificity, even within a sub-species, when related to efficient utilization of Human Milk Oligosaccharides (HMOs).

Several species of Bifidobacterium have been shown to utilise HMOs, but little work has been done to study utilization variations within the species or sub-species. This study examined two strains of B. infantis, a prevalent species in the guts of breastfed infants. The study found that B. infantis Bi-26 has a unique strategy to quickly utilize 2-Fucolsyllactose (2’-FL), 3’-FL and difucosyllactose (DFL) which results in faster growth, unique metabolite production, and a distinct global gene transcription response when compared to the type strain ATCC 15697 (reference strain for the B. infantis subspecies).

Said Bryan Zabel, assistant scientist, DuPont Nutrition & Biosciences – the study’s lead author: “We are excited to further the research on defining the individual strain’s role within the complex system of the microbiome. It is essential to understand the numerous interactions affecting our health throughout life which can eventually be used as a guide to develop products for supplementation.”

Added Dr. Ratna Mukherjea, Technical Fellow and Technology & Innovation Leader, Specialised Nutrition, DuPont Nutrition & Biosciences: “Our research helps us to further understand the interactions between probiotic strains and HMOs and allows us to develop targeted health products. This study marks a significant advancement in DuPont’s work in early life nutrition.” For more or to read the full study visit nature.com/articles/s41598-020-72792-z

David Cox / IDM

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